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Cell cycle arrest by SIM in NCI-H460 cells via inhibition of Cdk4 and Cyclin D, in which the effects of CDK inhibitors p16 and p27 were enhanced: Cells were treated with SIM followed by (A) In-cell Western blot analysis (B) Western blot analysis (C and D) Quantification of band intensities by Li-COR near infrared imaging system. Significant differences were determined at a level of * p < 0.05 versus the 0 μM control group.
