Table 1.
Drug resistance associated mutations, frequency and coding nucleotides in HIV-1 subtype C integrase sequences from northeastern South Africa.
| Sample code | Integrase mutation | Frequency | Coding nucleotides | Comment | |
|---|---|---|---|---|---|
|
| |||||
| Wild type | mutant | ||||
| 08BBVCT73ZA | L74M | 1/89 (1.1%) | CTG | ATG | Polymorphism (Stanford); minor mutation involved in the Q148H/K/R pathway to Raltegravir resistance (IAS). |
| 08BBVCT27ZA | Q95K | 1/89 (1.1%) | CAA | AAA | Minor mutation to Raltegravir (Stanford); not documented in IAS algorithm |
| 08MB33ZA | Q95P | 1/89 (1.1%) | CAA | CCA | Unusual mutation (Stanford); not documented in IAS algorithm. |
| 08BBVCT49ZA | E157K | 1/89 (1.1%) | GAA | AAA | Unusual mutation (Stanford); mutation not documented in IAS algorithm. |
| 08BBVCT38ZA | I203M | 1/89 (1.1%) | ATA | ATG | Polymorphism; but not documented in IAS algorithm. |
| 08MB34Z | R263S | 1/89 (1.1%) | AGG | AGC | Unusual mutation by Stanford; but not documented in IAS algorithm. |