Table 1.
Receptors, ligands, E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) of the Notch pathway.
| Component function | Drosophila | Caenorhabditis elegans | Mammals |
|---|---|---|---|
| Receptor | Notch | LIN-12, GLP-1 | Notch 1–4 |
|
| |||
| Ligand (DSL) | Delta | APX-1, LAG-2, ARG-2, DSL1-7 | Dll 1, 3, 4 |
| Serrate | Jagged 1, 2 | ||
|
| |||
| E3 ubiquitin ligase | Mindbomb1–2 | Mindbomb 1, 2 (skeletrophin) | |
| Neuralized | Neuralized 1, 2 | ||
| Deltex | Deltex 1–4 | ||
| Nedd4, Su(Dx) | WWP-1 | Nedd4, Itch/AIP4 | |
| Archipelago | SEL-10 | Fbw-7/SEL-10 | |
| d-cbl | Cbl | ||
| Mdm2 | |||
|
| |||
| DUB | USP12 (CG 7023) | USP12 | |
| eIF3-S5 (CG 9769) | eIF3f | ||