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Effect of FA saturation on α-secretase activity. Phospholipids containing monoor polyunsaturated FAs were exposed to (A) purified membranes of SH-SY5Y wt cells and living SH-SY5Y wt cells (B) purified membranes of human post mortem brains (C) purified α-secretase ADAM10 in the presence of human brain lipid extract. (A,B,C) Phospholipid concentration, determination of α-secretase activity, illustration and statistical significance as described for Figure 1.
