Table 1.

Summary of the effects of different phospholipids on α-secretase activity.

	SH-SY5Y membranes	living SH-SY5Y cells	purified ADAM10	human post mortem brain
	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)
Effect of chain length
PC 10:0	127.7 (2.2 n.s.)	124.8 (1.3 ***)
PC 12:0	144.0 (9.3 **)	126.9 (1.3 ***)	132.0 (9.6 *)	141.9 (7.6 **)
PC 14:0	128.0 (11.9 n.s.)	103.5 (1.2 n.s.)
PC 16:0	99.8 (5.9 n.s.)	99.2 (1.3 n.s.)
PC 18:0	100.0 (3.2)	100.0 (2.3 n.s.)	100.0 (6.4)	100.0 (5.7)
PC 20:0	102.3 (0.5 n.s.)	98.8 (1.9 n.s.)
PC 22:0	98.8 (1.9 n.s.)	100.1 (2.3 n.s.)
PC 24:0	101.7 (1.5 n.s.)	107.8 (2.2 n.s.)
	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)
Effect of headgroup
PC 12:0	100.0 (0.7)	100.0 (1.1)		100.0 (4.5)
PE 12:0	98.5 (1.3 n.s.)	93.6 (2.8 n.s.)		109.2 (3.1 n.s.)
PS 12:0	93.4 (2.5 n.s.)	83.8 (1.6 **)		104.9 (3.7 n.s.)
PC 14:0	100.0 (1.9)	100.0 (1.1)		100.0 (10.9)
PE 14:0	101.0 (1.5 n.s.)	105.0 (4.0 n.s.)		105.7 (3.6 n.s.)
PS 14:0	116.2 (3.1 ***)	96.6 (2.0 n.s.)		104.7 (12.2 n.s.)
	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)
Effect of saturation
PC 18:0	100.0 (1.2)	100.0 (2.3)	100.0 (4.8)	100.0 (3.1)
PC 18:1	102.0 (1.5 n.s.)	110.3 (4.3 n.s.)
PC 18:2	97.1 (2.1 n.s.)	115.0 (6.6 n.s.)
PC 18:3	98.2 (2.0 n.s.)	117.4 (2.3 n.s.)	148.2 (4.2 ***)	106.3 (2.7 n.s.)
PC 20:4	104.2 (4.8 n.s.)	124.7 (2.0 **)
PC 20:5	123.1 (7.6 **)	140.1 (14.2 ***)
PC 22:6	108.6 (2.6 n.s.)	136.8 (2.2 ***)	229.7 (2.7 ***)	152.0 (17.4 **)
	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)	Mean % (SEM % +/− Sign.)
Effect of double-bond position
PC 18:1D9	100.0 (1.8)	100.0 (4.4)
PC 18:1D6	106.1 (1.0 *)	101.7 (4.5 n.s.)

Asterisks show the statistical significance (

^*p ≤ 0.05;

^**p ≤ 0.01 and

^*** p ≤ 0.001, n.s. not significant).