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. 2013 Mar 15;14(3):6044–6066. doi: 10.3390/ijms14036044

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Schematic presentation of the stimuli that induce MT and the downstream effects of MT overexpression. MT can be activated by a variety of stimuli, including metal ions, cytokines, growth factors, oxidative stress and radiation. Downstream effects of MT overexpression are modulation of transcription of both tumor suppressor protein p53 and nuclear transcription factor NF-κB. Another downstream effect of MT overexpression is free radical scavenging activity. All these downstream MT effects influence cell survival, cell growth, drug resistance and differentiation. Adopted and modified according to [107].