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. 2013 Mar 4;14(3):5239–5249. doi: 10.3390/ijms14035239

Figure 2.

Figure 2

Results of the multivariate analyses on the main experiment. (a) Unsupervised cluster analysis generated on the expression levels of let-7a, let-7b, miR-16 and miR-185. Single cases are labeled as green, olive or red depending on their group affiliation (TN-nPSA group, TN-hPSA group and TP group respectively); (b) Classification results of the discriminant function generated on the expression level signature of let-7a, let-7b, miR-16 and miR-185; (c) receiver operating characteristic (ROC) curve for the estimation of sensitivity and specificity of the discriminators let-7a, let-7b, miR-16 and miR-185 and the discriminant function. Note that the area under the curve (AUC) of the signature (represented by the discriminant function) is larger than the AUCs of the single microRNAs.