Table 4.

Diseases and affected PLA₂ expressions in human patients and in knockout mice.

Types of PLA2	Expression levels	Diseases	References
sPLA2-IIA	Highly expressed in synovial fluid	RA	[123,126,165,166,169]
sPLA2-IIA	Highly expressed in chondrocytes	RA	[126]
sPLA2-IID	Overexpressed in synovial fluid	RA	[124]
sPLA2-IIE	Overexpressed in synovial fluid	RA	[124]
sPLA2-V	Overexpressed in synovial fluid	RA	[124]
sPLA2-X	More or less expressed in synovial fluid	Active and inactive RA	[124]
sPLA2-IIA	Overexpressed in synovial fluid	OA	[126,167,168]
sPLA2-IIA	Overexpressed in VSMC	Infarctus heart	[164]
sPLA2-V	Overexpressed in VSMC	Infarctus Heart	[164]
cPLA2-α	cPLA2-α−/− mice loss in function	Prevention in collagen-induced arthritis	[174]
iPLA2β	iPLA2-β−/− mice loss in function	Low bone mass	[121]