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Human VEGFR is more homologous to S. sq VEGFR than to Amphioxus VEGFR-like protein. (a) Comparison of the KD2 domain among S. sq VEGFR, Amphioxus VEGFR-like molecule and human VEGFRs; (b) Comparison of KD2 domain in S. sq VEGFR with invertebrate VEGFRs and human VEGFRs as well as PDGFRs; (c) Diagram of Phylogenic tree (the order of ascidians such as H. roretzi and amphioxus is not completely fixed).
