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. 2012 Dec 20;6(3):643–651. doi: 10.1242/dmm.010330

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — Immunosuppression with FK506 and hydrocortisone leads to increased inflammation in invasive pulmonary aspergillosis. Groups of three mice were either untreated or immunosuppressed with FK506, hydrocortisone or both and culled at 48 hours after infection. Lungs were fixed and three PAS stained sections from each mouse scored with ImageJ software by threshold analysis for the amount of inflammation. (A) Percentage of lung area inflamed (histopathology). (B) Representative Grocott-stained (right) and H&E-stained (left) lung sections for the combined FK506-hydrocortisone model, demonstrating airways occluded by inflammatory cells and fungal germlings, together with inflammation in and around the airway and damage to the bronchial epithelium. IC, immunocompetent; HC, hydrocortisone.