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. 2013 Jan 11;6(3):661–678. doi: 10.1242/dmm.010066

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 9. — TNF (Eiger) is required for apoptosis in rok^CAT clones. Confocal planar compiled sections through the epithelium of third instar larval EADs. Mutant clones are marked by the presence of GFP (white, and green in the merge) and TUNEL (white, and red in the merge). (A) FRT82B control. (B) rok^CAT. (C) egr^1/3rok^CAT. Third instar EADs from rok^CAT mosaic larvae show higher levels of apoptotic cells, as revealed by TUNEL, both cell autonomously (arrows, Bi,Bii) and non-cell autonomously (arrowheads, Bi,Bii). Removing egr reduced, but did not eliminate, apoptotic cells in the rok^CAT EAD in both rok^CAT (arrows, Ci,Cii) and wild-type clones (arrowheads, Ci,Cii). (D) Quantification of the number of TUNEL-positive cells in EADs of each genotype indicated. The data was compared by a t-test and error bars represent s.e.m. The significance was P<0.05 for rok^CAT compared with the FRT control, and for rok^CAT compared with egr^1/3rok^CAT. (E) Quantification of the percentage of mutant clonal tissue relative to the total EAD size for each genotype indicated. The data was compared by a t-test and error bars represent s.e.m. The significance was P<0.05 for scrib¹ compared with egr^1/3 scrib¹, for scrib¹ compared with FRT, and for egr^1/3scrib¹ compared with FRT.