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. 2013 Feb 8;6(3):710–720. doi: 10.1242/dmm.011445

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Tamoxifen-induced PTEN deletion causes rapid and reproducible development of endometrial hyperplasia and in situ adenocarcinoma of the endometrium. (A–D) Comparison of histopathology and PTEN expression of Cre-ER^T+/−PTEN^fl/fl mice injected with tamoxifen (TAM) or corn oil (CON) at different time points. (A–C) Representative images showing PTEN immunohistochemistry (bottom panels) and H&E staining (top panels) of uterus from mice sacrificed in weeks 0–2 (A), weeks 3–5 (B) or weeks 6–8 (C) after tamoxifen injection. (D) Graph showing the percentages of endometrial lesions distributed by periods of time.