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. 2013 Feb 1;6(3):721–733. doi: 10.1242/dmm.010710

Fig. 5.

Fig. 5.

TDP-43 variants affect the growth and function of the neuromuscular junction synapse. (A–F) Neuromuscular junctions in larvae expressing TDP-43 driven by D42 Gal4 were labeled by CSP (synaptic vesicle marker) and HRP (neuronal membrane marker). (G) Quantification of synaptic boutons indicates a reduction in synaptic size due to TDP-43 overexpression. (H) Larvae expressing TDP-43 in motor neurons are impaired in larval turning behavior. (I–N) Neuromuscular junctions in larvae expressing TDP-43 driven by repo Gal4 were labeled by CSP (synaptic vesicle marker) and HRP (neuronal membrane marker). (O) Quantification of synaptic boutons indicates a decrease in synaptic size due to TDP-43 overexpression. (P) Larvae expressing TDP-43 in glia are impaired in larval turning behavior. Values show means ± s.e.m. All comparisons were performed using D42 Gal4 driver controls and Student’s t-test was used to calculate significance; *P<0.5, **P<0.01, ***P<0.001. Scale bars: 30 μm.