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. 2013 Feb 1;6(3):721–733. doi: 10.1242/dmm.010710

Fig. 7.

Fig. 7.

TDP-43 overexpression affects sleep and locomotor activity in adult flies. (A–F) TDP-43 variants were expressed in motor neurons using D42 Gal4. Measurements using DAMs show that locomotor activity is significantly reduced overall (A) and total sleep is significantly altered, with wild-type TDP-43 leading to longer overall sleep than the mutant variants (B). During the day (C,D) as well as during the night (E,F), TDP-43 expression results in significantly more sleep episodes (D,F) that last shorter intervals of time (C,E). (G–L) TDP-43 variants were expressed in glial cells using repo Gal4. Measurements using DAMs show variable effects on locomotor activity (G) and a significant reduction in total sleep (H). During the day (I,J) there are variable effects on sleep. During the night (K,L), TDP-43 expression in glia results in significantly more sleep episodes (L) that last shorter amounts of time (K). Values show means ± s.e.m. All comparisons were performed using D42 Gal4 driver controls and significance was determined using a non-parametric Wilcox test calculated in R; *P<0.5, **P<0.01, ***P<0.001.