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. 2013 Feb 8;6(3):734–744. doi: 10.1242/dmm.010017

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — Long chain TAGs and fatty acids are utilized differentially upon starvation in wild-type and itpr^ku adults. (A–D) TAG profiles (left) and fatty acid content (right) in abdomen of the indicated genotypes under 144 hours fed (F) and 72 hours fed plus 72 hours starved (S) conditions. TAG levels were normalized to the most abundant TAG 46:1, which was set to 100%. (A) CS flies retain longer chain TAGs under starvation (arrows), whereas (B) in itpr^ku flies long and short chain TAGs remain the same in both conditions. A corresponding change is observed in the fatty acid content (FA) of TAGs. Abundance of fatty acids was derived from MS/MS analysis of abdominal TAG fractions and normalized to the most abundant FA (14:0). On starvation, wild-type flies (CS) show increased levels of FA 18:0, 18:1 and 18:2, 18:3 and 20:0 (*P<0.05, ANOVA, post-hoc Bonferroni test). This differential utilization of TAGs with short chain fatty acids is absent in itpr^ku. (C) Expression of an itpr⁺ cDNA in the IPCs of itpr^ku restored TAG and FA profiles back to those of the wild type, whereas (D) dilp2⁺ overexpression (panels marked as rescue) in IPCs restored TAG and FA profiles partially.