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. 2013 Feb 14;6(3):745–754. doi: 10.1242/dmm.011205

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Immunohistochemical results for Bcl-2. Brown staining marks Bcl-2 activity. (A) Overview of the cochlea duct at the middle turn. The box marks the organ of Corti, with intensive Bcl-2 staining. Further reactivity can be seen in the spiral ligament. (B) Close-up of the organ of Corti. With the differential interference contrast mode, the inner and outer hair cells do not show any Bcl-2 activity. High Bcl-2 activation is seen for the Deiters’ cells, Hensen’s cells, Claudius’ cells and other supporting cells. (C) High magnification of the stria vascularis and the spiral ligament. Upregulation of Bcl-2 in the fibrocytes of the spiral ligament can be noted. No reaction is found in the stria vascularis. (D) Bcl-2 activation can be seen in the spiral ganglion cells. OHC, outer hair cell; IHC, inner hair cell; CC, Claudius’ cells; DC, Deiters’ cells; HC, Hensen’s cells; SL, spiral ligament; SV, stria vascularis.