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. 2013 Feb 21;6(3):755–767. doi: 10.1242/dmm.011668

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 1. — The katun mouse strain carries a mutation in Zic3. (A–C) Sequence traces from exon 1 of the murine Zic3 gene, with arrows indicating the altered base. (A) The parental C3H/HeH and BALB/c OlaHsd alleles have a G at position 1283 of accession number NM_009575. (B) Female carriers of the mutation have a G/T heteroduplex at this position. (C) Male hemizygotes have a G to T transversion at this position. (D) Representation of the Zic3 protein showing the position of the katun (E249X) mutation relative to other protein features, including the C2H2 zinc fingers (dark blue), amino acid repeat regions (blue; A, alanine repeat; H, histidine repeat), the Zic-Opa conserved (ZOC) motif (bright green) and the zinc finger N-flanking conserved (ZF-NC) region (light green).