Figure 7.

Model for the Regulation of ACS Stability.

The ETO1/EOL E3 ligases target the type-2 ACS proteins for degradation by the 26S proteasome, and 14-3-3 increases degradation of the ETO1/EOLs via promotion of the ubiquitination of ETO1/EOLs, thus stabilizing these ACS proteins. 14-3-3 also directly interacts with all three classes of ACS proteins, likely through a phosphorylation-dependent mechanism, to increase their stability. See text for additional details.

[See online article for color version of this figure.]