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. 1988 Jun;8(6):2651–2654. doi: 10.1128/mcb.8.6.2651

B-raf, a new member of the raf family, is activated by DNA rearrangement.

S Ikawa 1, M Fukui 1, Y Ueyama 1, N Tamaoki 1, T Yamamoto 1, K Toyoshima 1
PMCID: PMC363468  PMID: 3043188

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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Selected References

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