Table 2.
Identified genes that contain the EGRF/ETSF promoter module in their promoter regions.
| Accession | Genea | Model score | Effect on proliferationb | Expression in colon cancerc | Public microarray datad | References |
|---|---|---|---|---|---|---|
| AB000381 | GML | 89% | negative | Yes - in cell lines | No | Oncogene 1996; 13 (9) 1965–7. Int J Clin Oncol. 2001 Apr; 6(2):90–6 |
| AB001517 | TMEM1 | 90% | ? | ? | No | |
| AB001523 | PWP2 | 90% | ? | ? | No | |
| AB003173 | WRN | 90% | positive | Yes – in unmethylated tumours | Yes | DNA Repair 2004; 3(5): 475–482 Proc Natl Acad Sci USA. 2006 Jun 6; 103(23):8822–7 |
| AB003469 | MCM5 | 90% | ? | Yes | Yes | Clin Cancer Res. 1999 Aug; 5(8):2121–32 |
| AB004270 | MCM7 | 90% | positive | ? | Yes | Oncogene 2006; 25(7): 1090–9 |
| AB005647 | NPR2 | 90% | ? | ? | No | |
| AB006075 | HMG-CoA synthase | 89% | ? | Yes | No | Mol Carcinog. 2001 Nov; 32(3):154–66. |
| AB006684 | AIRE | 91% | ? | ? | No | |
| AB007828 | NDN | 88% | negative | ? | No | Gene 1998; 213(1–2): 65–72 |
| AB008496 | COL4A3 | 90% | negative | ? | No | J Biol Chem 2000; 275 (28):21340–8 |
| AB008502 | TLX2 | 90% | ? | ? | No | |
| AB008681 | ACVR2B | 92% | positive | Yes – in cell lines | No | Dev Biol 2004; 266(2): 334–45 Gut. 2001 Sep; 49(3):409–17 |
| AB008822 | TNFRSF1 1B | 92% | negative | ? | No | J Clin Invest 2001; 107(10):1235–4 |
| AB009071 | KCNH2 | 88% | positive | Yes | Yes | J Biol Chem 2003; 278(5):2947–55 Cancer Res. 2004 Jan 15; 64(2):606–11 |
| AB009667 | Klotho | 95% | ? | ? | No | |
| AB009777 | NID2 | 85% | ? | ? | No | |
| AB012286 | ITGB4 | 90& | positive | ? | Yes | Cancer Res 2005; 65(23):10674–9 |
| AB012668 | hFUCT-7 | 91% | ? | ? | No | |
| AB015751 | APLP2 | 96% | ? | ? | No | |
| AB016243 | SLC9A3R2 | 91% | ? | ? | No | |
| AB016656 | LIMK2b | 91% | ? | ? | No | |
| AB016767 | TERT | 95% | ? | ? | No | |
| AB017018 | HNRPDL | 94% | ? | ? | Yes | |
| AB017547 | SPR | 93% | ? | ? | Yes | |
| AB017567 | LIPT1 | 95% | ? | ? | No | |
| AB017602 | PDE9A | 90% | ? | ? | Yes | |
| AB018192 | PHC1 | 95% | ? | ? | No | |
| AB018401 | DHH | 90% | positive | ? | No | Development 2004 Oct; 131(20):5009–19 |
| AK001326 | TSPAN3 | 90% | positive | ? | Yes | J Cell Biol 153:295–305 |
a.
HUGO accepted gene name
b.
Published experimental evidence of effect on cell proliferation
c.
Experimental evidence of increased protein or mRNA expression in colon cancer
d.
Upregulation of gene in public microarray database of expression relative to normal (Diehn et al. 2003)