Figure 1.

The Structure and Functions of YB-1. YB-1 is made up of the N-terminal, cold shock (CSD) and C-terminal domains (CTD). These domains have unique functions. The N-terminal is necessary for transactivation whereas the CSD is important for RNA/DNA binding. Most of the characterized protein:protein interactions occur on the CTD. The CSD and CTD also work together to facilitate nuclear trafficking. Cellular trafficking is furthermore regulated by the nuclear localization signal in the C-terminal domain as well as the cytoplasmic retention signal also located in this region of the protein.