Table 2. Enhanced effect of CBD and THC on LPS-upregulated genes.
| Gene Name | Description | Accession | Fold Change (versus untreated) | Effect on LPS | |||||
| Anti-inflammatory cytokines | LPS | CBD+LPS | THC+LPS | CBD | THC | CBD | THC | ||
| Gdf15 | growth differentiation factor 15 | NM_011819.2 | 8.1 | 55.7 | 15.5 | 8.2 | 2.4 | 592% | 92% |
| Regulatory molecules | |||||||||
| Sqstm1/p62 | sequestosome 1 | NM_011018 | 2.3 | 5.1 | 3.3 | 3.2 | 1.2 | 117% | 40% |
| Membrane transport and secretion | |||||||||
| Slc7a11 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 | NM_011990.1 | 8.0 | 20.5 | 10.1 | 7.1 | 1.7 | 157% | 26% |
| Aqp9 | aquaporin 9 | NM_022026.2 | 3.1 | 30.3 | 4.8 | 14.3 | 2.0 | 877% | 55% |
| Mcoln2 (TRPML2) | mucolipin 2 | NM_026656.4 | 2.8 | 5.7 | 3.6 | 1.8 | 1.3 | 104% | 28% |
| Phosphatases | |||||||||
| Dusp1 (MKP-1) | dual specificity phosphatase 1 | NM_013642 | 2.5 | 5.1 | 2.9 | 2.8 | 1.1 | 103% | 16% |
| Dusp8 | dual specificity phosphatase 8 | NM_008748 | 2.5 | 5.1 | 2.5 | 1.6 | 1.0 | 107% | 0% |
| G protein-coupled receptors | |||||||||
| Ptgir | prostaglandin I receptor | NM_008967.1 | 3.8 | 11.7 | 4.3 | 5.4 | 1.3 | 207% | 13% |
| Apoptosis | |||||||||
| Lcn2 | lipocalin 2 | NM_008491.1 | 13.3 | 69.1 | 10.9 | 2.5 | 2.5 | 421% | −18% |
| Regulation of transcription | |||||||||
| Nupr1 | nuclear protein 1 | NM_019738.1 | 4.3 | 8.8 | 5.4 | 7.9 | 2.0 | 107% | 27% |
| Jundm2 | Jun dimerization protein 2 | NM_030887.2 | 3.0 | 6.5 | 4.1 | 3.0 | 1.5 | 117% | 38% |
| Cell cycle and proliferation | |||||||||
| Cdkn2b | cyclin-dependent kinase inhibitor 2B (p15,inhibits CDK4) | NM_007670.2 | 2.2 | 9.1 | 3.1 | 2.9 | 1.1 | 314% | 41% |
| Stress response | |||||||||
| Herpud1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | NM_022331.1 | 3.2 | 4.4 | 4.6 | 3.3 | 2.3 | 37% | 42% |
| Adhesion and migration | |||||||||
| Clecsf9 * | C-type (calcium dependent, carbohydrate recognition domain) lectin | NM_019948.2 | 20.3 | 32.3 | 26.5 | 2.3 | 1.7 | 59% | 30% |
| Vil2/Ezrin | villin 2 | NM_009510.2 | 2.6 | 5.4 | 2.9 | 1.6 | 1.0 | 110% | 12% |
*
gene involved in proinflammatory signaling.