Table 3. Opposing effects of CBD and THC on LPS-downregulated genes.

Gene Name	Description	Accession	Fold Change (versus untreated)					Effect on LPS
Adhesion and migration			LPS	CBD+LPS	THC+LPS	CBD	THC	CBD	THC
Cd28 *	CD28 antigen	NM_007642.2	−4.1	−2.1	−3.3	1.3	−1.2	−49%	−20%
Nrp1	neuropilin 1	NM_008737.1	−3.4	0.0	−2.2	1.6	−1.1	−100%	−33%
Unc5b	unc-5 homolog B (C. elegans)	NM_029770.1	−2.9	1.4	−2.4	1.7	−1.4	−53%	−15%
Motility and morphogenesis
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	NM_017464.2	−2.8	−0.9	−2.3	−1.0	−1.4	−69%	−20%
Membrane transport and secretion
Kcnk13	potassium channel, subfamily K, member 13	NM_146037.1	−2.2	−1.3	−1.6	−0.9	−0.9	−42%	−27%
Regulation of transcription
Sox4	SRY-box containing gene 4	NM_009238.1	−3.1	−1.8	−2.8	2.1	0.9	−42%	−10%
Bhlhb2	basic helix-loop-helix domain containing, class B2	NM_011498.4	−2.5	−1.1	−1.9	1.0	1.0	−56%	−24%

^*gene related to inflammatory responses.