Table 4. Potentiated effect of CBD and THC on LPS-downregulated genes.

Gene Name	Description	Accession	Fold Change (versus untreated)					Effect on LPS
Stress response			LPS	CBD+LPS	THC+LPS	CBD	THC	CBD	THC
Sesn1	sestrin 1	NM_001013370.2	−4.4	−6.3	−4.2	−1.7	−1.1	43%	−3%
Hspa5bp1	heat shock 70 kDa protein 5 binding protein 1	NM_133804.1	−3.6	−5.8	−4.1	−1.0	−1.5	64%	14%
Proinflammatory chemokines
Cxcl14	chemokine (C-X-C motif) ligand 14	NM_019568.2	−1.1	−2.1	−1.2	−2.6	−1.4	93%	11%
Metabolic enzymes
Chst10	carbohydrate sulfotransferase 10	NM_145142.1	−3.2	−5.0	−4.3	−2.2	−1.8	59%	38%
Cell cycle and proliferation
Klhl6	kelch-like 6 (Drosophila)	NM_183390.1	−8.0	−13.7	−9.1	−1.9	−1.4	72%	13%
Rasgrp3	RAS guanyl releasing protein 3	NM_207246.2	−2.7	−4.5	−2.4	−1.4	−1.1	66%	−13%
Ccnd1	cyclin D1	NM_007631.2	−2.4	−6.0	−2.8	−2.9	−1.2	155%	20%
Zfp36l1	zinc finger protein 36, C3H type-like 1	NM_007564.2	−2.0	−3.2	−2.2	−1.1	−1.0	61%	9%
Motility and morphogenesis
Pscdbp *	pleckstrin homology, Sec7 and coiled-coil domains, binding protein	NM_139200.4	−5.2	−11.0	−7.3	−2.1	−1.7	111%	40%
Phosphatases
Pald	paladin	NM_013753.1	−3.0	−5.7	−3.3	−2.0	−1.2	88%	9%
Kinases
Sbk	SH3-binding kinase	NM_145587.1	−2.2	−3.2	−2.3	−1.2	−1.2	51%	8%
G protein-coupled receptors
Ebi2	Epstein-Barr virus induced gene 2/GprPR183	NM_183031.2	−9.1	−16.6	−10.6	−2.4	−1.3	82%	16%
Regulation of transcription
Mef2c	myocyte enhancer factor 2C	NM_025282.1	−2.1	−4.1	−2.3	−2.1	−1.2	95%	11%

^*gene related to inflammatory responses.