Table 5. Simulation conditions and respective fittings (α = 0.05) to the generalized CA model in the specified examples.

receptors (α1 = α2)		80;32	80;32	80;32	80;32	80;32	80;32	60;24
λ1 threshold		120;48	120;48	120;48	120;48	120;48	120;48	120;48
λ2 threshold		120;48	120;48	120;48	120;48	120;48	120;48	120;48
tox (D2)		1	0.7	1	1	1	1	1
q [D1↑↓D2]		-	-	0.02 [D1↑D2]	0.04 [D1↓D2]	0.02 [D1↓D2]	-	-
q [D2↑↓D1]		-	-	0.02 [D2↑D1]	-	0.01 [D2↓D1]	-	-
q [D1↑↓α2]		-	-	-	-	-	0.004 [D1↓α2]	-
q [D2↑↓α1]		-	-	-	-	-	0.001 [D2↓α1]	-
q [D1↑↓λ2]		-	-	-	-	-	-	0.02 [D1↓λ2]
q [D2↑↓λ1]		-	-	-	-	-	-	-
		null equipotent	null non-equipotent		unidirectional	recipr. asymm.	recipr. receptor	recipr. threshold
		interaction	interaction	synergy	antagonism	antagonism	modification	modification
Basic parameters of the	K	0.874±0.0006	0.874±0.0006	0.873±0.0004	0.874±0.001	0.874±0.002	0.915±0.007a	0.700±0.006a
joint response	m	0.426±0.0007	0.610±0.0013	0.426±0.0009	0.427±0.001	0.426±0.001	0.422±0.002a	0.390±0.003a
	a	2.772±0.0160	2.786±0.0138	2.776±0.0181	2.784±0.016	2.778±0.016	2.850±0.040a	2.813±0.055a
perturbations due to D1	b2	0	0	7.955±0.075	0	0	0	0
modifying the actual dose D2	c2	0	0	0	7.986±0.068	4.009±0.024	0	0
perturbations due to D2	b1	0	0	0	0	0	0	0
modifying the actual dose D1	c1	0	0	0	0	2.006±0.012	0	0
Relative potency factor	u	1	1.428±0.005	1	1	1	1	1
Perturbations due to D1	bk2	0	0	0	0	0	0	4.325±0.297
modifying the common parameters	ck2	0	0	0	0	0	0.265±0.008	2.738±0.192
	bm2	0	0	0	0	0	0	−0.611±0.030
	bm2	0	0	0	0	0	0	0
Perturbations due to D2	bk1	0	0	0	0	0	0	0
modifying the common parameters	ck1	0	0	0	0	0	0.116±0.007	0
	bm1	0	0	0	0	0	0	0
	bm1	0	0	0	0	0	0	0
	r2	0.9999	0.9999	0.9999	0.9998	0.9998	0.9992	0.9994

Notations as in Table 4. See also Figure 9 and Figure 10.

(^a) apparent parameter (see text).