Table 1. Clinical characteristics of the MS patients included in the genetic study.

	NORTHERN SPANISH-BASQUE				REPLICATION DATASET
	BILBAO		SAN SEBASTIÁN		UCSF WHITES		ANDALUCÍA		MADRID
	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases
Participants
Total number	565	573	249	250	450	507	1340	1119	810	639
% Male/Females	31.2/68.8	26.5/73.5	34/66	38/62	32.9/67.1	32/68	27.3/62.7	26.8/62.5	45.4/53.2	34.7/62.8
/Unknown	/0	/0	/0	/0	/0	/0	/0	/10.7	/1.4	/2.5
Disease course (%)
RR & SP/PP/PR	–	87.6/10/0	–	88/2/0/	–	79.7/3.1/0.4/16.8/0	–	82.2/1/0.3 0.5/15.9	–	83.3/9.7/0.1
/other/no details		/1.6/0.8		/0.8/9.2						/0.5/6.4
Age at Onset
Mean ± S.D.	–	30.5±10.10	–	31.6±10.3	–	33.3±9.3	–	29.4±9.9	–	28.9±8.9
EDSS
Mean ± S.D	–	3.08±2	–	3.91±2.6	–	2.04±1.96	–	3.2±1.8	–	2.9±2.3

Abbreviations: RR = Relapsing-remitting, SP = Secondary progressive, PP = Primary progressive, PR = Primary relapsing, S.D. = Standard deviation.