Table 3. Replication and combined analysis of the most significant SNPs.
| REPLICATION | COMBINED | |||||
| SNPs (1) | P CMH | P BD | OR(2) (95% CI) | P CMH | P BD | OR(2) (95% CI) |
| rs11230548 (A/C) | 0.64 | 0.25 | 0.97 (0.85–1.1) | 0.85 | 0.17 | 1.01 (0.90–1.13) |
| rs17824933 (G/C) | 0.02 | 0.44 | 1.14 (1.02–1.27) | 0.005 | 0.58 | 1.16 (1.04–1.28) |
| rs916811 (A/G) | 1.00 | 0.49 | 1 (0.89–1.13) | 0.45 | 0.32 | 1.04 (0.94–1.16) |
| rs11230559 (C/T) | 0.02 | 0.20 | 1.14 (1.02–1.27) | 0.005 | 0.31 | 1.15 (1.05–1.27) |
| rs11230563 (T/C) (3) | 0.77 | 0.69 | 0.98 (0.89–1.09) | 0.88 | 0.83 | 0.99 (0.91–1.09) |
| rs2074225 (C/T) | 0.03 | 0.53 | 1.14 (1.01–1.25) | 0.0065 | 0.67 | 1.14 (1.04–1.25) |
| rs650258 (T/C)(4) | 0.08 | 0.46 | 1.085 (0.99–1.19) | 0.003 | 0.30 | 1.12 (1.04–1.21) |
Abbreviations: CMH = Cochran-Mantel-Haenszel test, BD = Breslow-Day test, OR = Odds ratio, CI = Confidence interval.
(1)
The risk alleles (with respect to the Basque dataset) are underlined.
(2)
The ORs are represented for the risk alleles found in the first-stage screen.
(3)
rs11230563 was included because it is a non-synonymous SNP that substitutes R225W, and showed a trend towards association in the first stage screen.
(4)
rs650258 was included based on the association observed in the Basque dataset.