Table 3. Group x task interaction effects on the task switching paradigm for the group of patients with obsessive-compulsive disorder (OCD), patients with major depressive disorder (MDD), and healthy controls. All activations at p<.001 uncorrected.
Regions | L/R | Cluster size | MNI coordinates | z-value | |||
x | y | z | |||||
Controls>OCD | |||||||
Anterior PFC | L | 2 | −27 | 51 | −12 | 3.50 | |
OCD>controls | |||||||
ACC | R | 3 | 0 | 15 | 27 | 4.58 | |
Postcentral gyrus | L | 7 | −48 | −18 | 30 | 3.98 | |
Putamen | L | 3 | −21 | 6 | 0 | 3.33 | |
Controls>MDD | |||||||
Parietal inf | R | 4 | 45 | −36 | 45 | 3.70 | |
Anterior PFC | R | 5 | 21 | 54 | 0 | 3.72 | |
MDD>controls No significant activations | |||||||
OCD>MDD | |||||||
Postcentral gyrus | L | 9 | −54 | −18 | 27 | 4.00 | |
Putamen | L | 2 | −21 | 0 | 6 | 3.56 | |
R | 3 | 24 | 15 | 3 | 3.49 | ||
Precuneus | R | 3 | 18 | −66 | 48 | 3.22 | |
Insula | L | 2 | −36 | −3 | 6 | 3.43 | |
L | 2 | −33 | −15 | 12 | 3.39 | ||
Supramarginal gyrus | L | 2 | −48 | −39 | 27 | 3.10 | |
MDD>OCD No significant activations |