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. 2013 Apr 24;8(4):e61982. doi: 10.1371/journal.pone.0061982

Figure 6. Schematic representation of the proposed model.

Figure 6

T3 induces a sustained increase in AT2R and AngI/II levels, which in turn causes the activation of PI3K pathway with the consequent increment in Akt phosphorylation that finally leads to an augmentation in NO production. Besides, T3 also causes a diminution in contractile protein levels. Altogether, these effects promote an increase in vascular relaxation. On the other hand, the specific blockade of AT2R (with PD123319) is able to partially or completely abolish the effects of T3, culminating in the prevention of the increase of vascular relaxation and evidencing the role of AT2R/PI3K/Akt pathway in these processes.