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. 2013 Apr 24;8(4):e61632. doi: 10.1371/journal.pone.0061632

Figure 4. Relative gene expression of key factors involved in salivary gland development, repair and regeneration.

Figure 4

qRT-PCR results at 8-week post-irradiation between Control, Irradiated (IR only) and BMSoup-treated mice. mRNAs were significantly up-regulated in BM Soup versus IR mice for MMP2 (an enzyme in tissue breakdown), BMP7, EGF, Cyclin D1 (cell cycle G1/Synthesis) and NGF (*P<0.05, **P<0.01; N = 5 mice per group). There was a downregulation of Sox2 (transcription factor in stem cell renewal). Y-axis shows the relative expression of the gene compared to GAPDH. Horizontal dashed line represents the relative gene expression level of 1 in mice from the Control group (sham-irradiated mice).