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. 2013 Apr 24;8(4):e61632. doi: 10.1371/journal.pone.0061632

Figure 8. BM Soup of both young and older mouse donors was as effective in repairing irradiated salivary glands.

Figure 8

A. At week 8 post-irradiation, salivary flow rate (SFR) of groups treated with BM Soup from both young (7–8 wks old) and older mouse donors (20–22 wks old) were comparable to sham-irradiated mice (Control) while the untreated mice (IR group) had 60% reduction in SFR. Both delivery routes for BM Soup (IG, intra-glandular; IV, intra-venous) were equally successful in re-establishing SFR to irradiated mice. B. The percentage of tissue surface area occupied by acinar cells was comparable between mice receiving BM Soup harvested from young and older donors, and from either an IV or IG injection delivery route. All mice treated with BM Soup had significantly a higher percentage of surface area with acinar cells than irradiated untreated mice (IR group). (*P<0.05, **P<0.01; N = 5 mice per group).