Table 2.

Results of Cox proportional hazards modeling for age at final menstrual period

	Primary Analyses			Sensitivity Analyses (Ages 40 – 55 Only)			Secondary Analyses (Omit surgery, chemotherapy, radiotherapy)
Model-BRCA vs. SWAN	HR (95% CI)	p-value	N	HR (95% CI)	p-value	N	HR (95% CI)	p-value	N
Unadjusted (all)			1147			937			805
BRCA	2.32 (1.74, 3.10)	<0.0001*		2.21 (1.30, 3.76)	0.0034*		4.38 (3.28, 5.85)	<0.0001*
SWAN	Reference			Reference			Reference
Unadjusted (all with complete data)			987			862			780
BRCA	4.06 (3.03, 5.45)	<0.0001*		2.69 (1.57, 4.62)	0.0003*		4.70 (3.50, 6.30)	<0.0001*
SWAN	Reference			Reference			Reference
Adjusted:(c)			987			862			780
BRCA	3.98 (2.87, 5.53)	<0.0001*		2.82 (1.56, 5.09)	0.0006*		4.33 (3.13, 6.01)	<0.0001*
SWAN	Reference			Reference			Reference
Parity:		0.4958			0.8565			0.4746
0	Reference			Reference			Reference
1	1.25 (0.83, 1.89)			1.03 (0.59, 1.79)			0.95 (0.62, 1.47)
2	1.21 (0.76, 1.93)			0.89 (0.56, 1.43)			0.80 (0.55, 1.17)
3+	0.97 (0.65, 1.47)			1.11 (0.66, 1.85)			0.75 (0.49, 1.14)
History of OCP use:		0.0659			0.0639			0.0631
No	Reference			Reference			Reference
Yes	0.72 (0.51, 1.02)			0.65 (0.41, 1.03)			0.72 (0.51, 1.02)
History of smoking:		0.0013*			0.0275*			0.0085*
Never	Reference			Reference			Reference
Past	1.27 (0.88, 1.85)			1.14 (0.74, 1.76)			1.12 (0.77, 1.62)
Current	2.01 (1.38, 2.93)			1.94 (1.19, 3.16)			1.79 1.23, 2.61)

^*statistical significance; (a) HR=hazard ratio, CI=confidence interval; (b) Multivariate model including as predictors for all variables in the table