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. Author manuscript; available in PMC: 2014 May 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Mar 13;23(10):3034–3038. doi: 10.1016/j.bmcl.2013.03.019

Figure 1.

Figure 1

Examples of cell-based efficacy of phenylthiophenes

A) HEK293pNFkBluc cells were treated where indicated with 5 ng/ml TNF for 5 h. A 3 h pre-treatment of a dose-response of 6 was performed where indicated and a Bright-Glo luciferase reaction was performed (SM methods); n>5. B) Permeability assays were performed (SM methods) following a dose-response of compound 6 and the addition of VEGF/TNF for 1.5 h; n≥7 combined from multiple independent experiments. Statistics were performed using One way ANOVA with Neuman-Keuls posthoc test in GraphPad.