Table 1.

SET-domain protein lysine methyltransferases in the yeast Saccharomyces cerevisiae

Protein	Substrate(s) (position given from the mature N- terminal residue unless otherwise indicated)	Product(s)	Methylated residue surface exposed or buried	References
Subfamily one
Set1 (as the catalytic component of the COMPASS complex)	histone H3 Lys-4 Dam1 Lys-233 (from initiator methionine)	trimethyl dimethyl (possible trimethyl)	surface unknown	[30]
Set2	histone H3 Lys-36	trimethyl	surface	[31]
Set3	no known methyltransferase activity
Set4	no known methyltransferase activity
Set5	histone H4 Lys-5, Lys-8, Lys12 histone H2A Lys-4, Lys-7	monomethyl at all three sites unknown	surface	[32]
Set6	no known methyltransferase activity
Subfamily two
Rkm1	ribosomal protein Rpl23ab Lys-105, Lys-109	dimethyl at both sites	surface (interface between small and large subunits)	[33]
Rkm2	ribosomal protein Rpl12ab Lys-3	trimethyl	surface	[25]
Rkm3	ribosomal protein Rpl42ab Lys-39	monomethyl	buried	[25]
Rkm4	ribosomal protein Rpl42ab Lys-54	monomethyl	buried (close contacts to 25S rRNA O2 of cytosine 2764 and OP2 of cytosine-93)	[25]
Efm1	elongation factor eEF1A Lys-30	monomethyl	surface	[34,35]
Ctm1	iso-1-cytochrome c Lys-72	trimethyl	surface	[36]