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Glutamine metabolism controls mTORC1. Top- Glutaminolysis, the metabolism of glutamine to α-ketoglutarate (αKG), is a two step process which results in the actiavtion of mTORC1. Glutamine is first de-aminated by glutaminase (GLS) to produce glutamate, and then glutamate dehydrogenase (GDH) produces a-KG. Bottom- In contrast, the synthesis of glutamine inhibits mTORC1 activation. Glutamine is synthesized by glutamine synthetase from glutamate.
