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Structure of GdDOTA-diBPEN-(Zn2+)2 (left). The r1 of this complex increases only slightly upon addition of Zn2+ ions in the absence of HSA but increases substantially (to ~17 mM−1s−1 at 23 MHz) in the presence of HSA (center). Difference MR image of a mouse abdomen (pixel intensities post- minus pre-injection of glucose and the Zn2+ responsive agent) showing highlighted regions of the pancreas (right).
