Table 1.

Studies showing limitation of conventional MRI.

Author	Evidence	Reference
Taal	18 out of 36 patients, (50%) were diagnosed with pseudoprogression 4 weeks after radiation therapy and concomitant temozolomide.	Taal et al. (2008)
Mullins	Individual patterns of enhancement are not enough to distinguish necrosis from predominant tumor progression.	Mullins et al. (2005)
Rachinger	For patients with glioma undergoing multimodal treatment or various forms of irradiation, conventional follow-up with MRI is insufficient to distinguish between benign side effects of therapy and tumor recurrence	Rachinger et al. (2005)