Table 1.

Overview of studies using human GEMs to study obesity and diabetes.

References	Topic/condition	Tissue(s)	Source network(s)	Modified network(s)
TOPOLOGY BASED ANALYSIS AND DATA INTEGRATION
Duarte et al., 2007	Gastric bypass surgery	Skeletal muscle	Recon 1	No modification
Capel et al., 2009	Calorie restriction	Adipose tissue	Recon 1, EHMN	No modification
Deo et al., 2010	Impaired glucose tolerance	Blood	Recon 1	Metabolic reaction network (MRN)
Zelezniak et al., 2010	Type 2 diabetes	Skeletal muscle	Recon 1, EHMN	No modification
Mutch et al., 2011	Calorie restriction	Adipose tissue	EHMN	No modification
Morine et al., 2011	Metabolic syndrome and n3 PUFA diet	Adipose tissue	EHMN	Transformation to an enzyme-centric network
CONSTRAINT BASED MODELING AND SIMULATION
Thiele et al., 2005	Diabetes	Heart	Mitochondrial	Extended mitochondrial
Becker and Palsson, 2008	Gastric bypass, glucose/insulin infusion, obesity	Skeletal muscle	Recon 1	Myocytes in different conditions
Bordbar et al., 2011	Type 2 diabetes	Liver, skeletal muscle, adipose tissue	Recon 1	Hepatocyte, myocyte, adipocyte
Mardinoglu et al., 2013a	Obesity	Adipose tissue	HMR	Adipocyte