Table 2.

Effect of Pb on Signal Transduction and Transcription Factors^a

		Signalb ± S.D.
GeneBank ID	Gene	Control	Pb	P-valuec
NM_010591	c-jun	1904 ± 70	2072 ± 106	0.04
AV026617	fos	7313 ±106	8106 ± 681	0.06
AB008192	Smad3	82 ± 38	288 ± 144	0.08
AI325183	Stat3	3288 ±160	3539 ± 313	0.14
D76446.1	Tak1	1052 ± 91	990 ± 130	0.32
NM_011951	Mapk1	12119 ±719	12998 ± 1083	0.15
NM_015806	Mapk6	1485 ± 107	1655 ± 73	0.04
BC024684	Mapk11(p38)	256 ± 32	358 ± 52	0.02
AF128892	Mapk14	3350 ± 173	3638 ± 171	0.06
BM240207	Map2k4	5412 ± 244	5894 ± 358	0.06
AW541674	Map2k7	1157 ± 77	1232 ± 69	0.14
AA929089	Map3k7	3832 ± 167	4152 ± 401	0.14
BF166991	Map4k2	500 ± 29	583 ± 80	0.08
BB734681	Map4k5	363 ± 50	490 ± 90	0.05
NM_016713	Map4k6	2589 ± 64	3086± 86	0.005
BG918951	Mapkapk2	783 ± 20	994 ± 91	0.009

^aAffymetrix MG430A GeneChip Data. The data represent mouse brain total RNA from female mouse pups from 3 litters of untreated control mice and 3 litters of 0.1 mM Pb acetate treated experimental mice.

^bSignal was normalized to the GAPDH signal on each respective GeneChip

^cStatistics were performed by means of a one-tailed Student’s t-test, significant at P≤0.05.