Table 5.
Compound | Mouse Microsomal Stability (t1/2, min) | Mouse Plasma Stability (t1/2, min) |
---|---|---|
5k | 25 | >120 |
5r | 5.9 | >120 |
6c | >700 | >120 |
7a | 88 | n.d. |
7b | 11 | n.d. |
7c | 190 | >120 |
7e | 45 | >120 |
8a | 33 | n.d. |
9 | 121 | n.d |
Compound | Mouse Microsomal Stability (t1/2, min) | Mouse Plasma Stability (t1/2, min) |
---|---|---|
5k | 25 | >120 |
5r | 5.9 | >120 |
6c | >700 | >120 |
7a | 88 | n.d. |
7b | 11 | n.d. |
7c | 190 | >120 |
7e | 45 | >120 |
8a | 33 | n.d. |
9 | 121 | n.d |