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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: J Med Chem. 2012 Sep 5;55(17):7759–7771. doi: 10.1021/jm3007917

Table 5.

Mouse liver microsome and plasma stability: n.d., not determined.

Compound Mouse Microsomal Stability (t1/2, min) Mouse Plasma Stability (t1/2, min)
5k 25 >120
5r 5.9 >120
6c >700 >120
7a 88 n.d.
7b 11 n.d.
7c 190 >120
7e 45 >120
8a 33 n.d.
9 121 n.d