Table 2.
Rates of Expansions of (GAA)100 in Wild-type and Hyper-GCR Mutants
| Genetic Background | Expansion Rate (×10−5) | Fold Increase |
|---|---|---|
| Wild-type | 1 (0.6–1)a | 1b |
| Double-strand break repair genes | ||
| Δsae2 | 1 (0.6–2) | 1 |
| Replication genes | ||
| TET-RFA2 | 171 (84–330) | 171 |
| TET-POL12 | 55 (49–82) | 55 |
| TET-PRI2 | 110 (77–190) | 110 |
| TET-POL3 | 11 (7–25) | 11 |
| TET-POL2 | 5 (2–12) | 5 |
| TET-POL30 | 26 (16–30) | 26 |
| TET-RFC2 | 26 (13–66) | 26 |
| TET-DNA2 | 8 (4–12) | 8 |
| TET-MCM4 | 23 (17–36) | 23 |
| TET-OCR4 | 18 (4–90) | 18 |
| Δrad27 | 20 (9–35) | 20 |
| Δrtt101 | 4 (2–31) | 4 |
| Δmms1 | 3 (2–4) | 3 |
| Δtof1 | 10 (13–24) | 10 |
| Telomere maintenance genes | ||
| TET-TEN1 | 12 (9–17) | 12 |
| TET-CDC13 | 14 (10–29) | 14 |
| Transcription initiation genes | ||
| TET-TAF4 | 58 (40–68) | 58 |
| TET-TAF9 | 37 (32–46) | 37 |
| TET-TOA1 | 14 (8–23) | 14 |
| TET-SUA7 | 19 (12–23) | 19 |
| TET-TFG1 | 22 (17–57) | 22 |
| TET-SPN1 | 2 (1–3) | 2 |
a
Numbers in parentheses correspond to the 95% confidence intervals.
b
Fold increase in rates of expansions in mutants compared to the wild-type strain.