Fig. 2.

Increase in dentate gyrus cellular BrdU incorporation in the tetanus toxin model of epilepsy. A) Immunohistochemical detection of BrdU + cells in ipsilateral dentate gyrus of control animal. B) Increased number of BrdU + cells in dentate gyrus of epileptic animals. BrdU + cells are located mainly in subgranular zone and granule cell layer. Several cells are also dispersed in hilus of the dentate gyrus. C) Counts of BrdU positive cells in dentate gyrus of the injected (“ipsilateral”) hippocampi show significantly more BrdU incorporating cells in epileptic rats (***p < 0.001; 8 animals in each group). Significant difference in BrdU + cell count was also observed dentate gyrus contralateral to the injection (*p < 0.05; 5 animals in each group).