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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Future Virol. 2013 Feb 1;8(2):129–157. doi: 10.2217/fvl.12.130

Table 1. Intravenous Macaca fascicularis challenges with Congo Basin strain (Zaire 79).

Dose Fever onset
(duration)		 Weight
loss (%)		 Lesion onset
(maximum lesion
count)		 Mortality/
euthanasia (days
of death)		 Blood vDNA
detected†
(duration of
detection)		 Infectious virus
from swabs
(duration of
detection)		 Ref.
107 Day 3 4–10 Day 3–6 (>1000) 2/6 (by day 18) Day 6 (to day 27) [23]
107 2–6 Day 5–6 (>2500) 4/4 (5, 7, 7, 7) Day 5–7 (to day 7) [48]
106 4–8 Day 6 (>1200) 4/6 (12, 12, 12, 14) Day 6–9 (to day 14) [48]
107 Day 3 (to day 7) 1–10 (>250) 8/8 (by day 9) Throat from day 2–6
Blood from day 5		 [102]
107 6–11 Day 4 (>1000) 4/6 (9, 9, 11, 14) Day 4 (to day 28) [103]
107 Day 3–4 (>1500) 3/3 (11, 12, 13) Day 4 (to day 13) [104]
107 Day 5–8 (>1400) 3/3 (9, 13, 13) Day 4 (to day 12) [105]
107 Day 3 (to day 9) 7–10 By day 6 (>750) 3/4 by day 15 Day 4 (to day 15) [106]
107 By day 6 (TNTC) 5/5 (11, 11, 11, 13,
15)		 Day 4 (to day 15) [107]
107 Day 3 (to
day 12)		 >4 Day 6 (>200) 3/3 (9, 11, 15) Day 3 (to day 15) [49]
†

Does not include detection at day 0 following intravenous challenge.

TNTC: Too numerous to count; vDNA: Viral DNA.