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. Author manuscript; available in PMC: 2013 Apr 25.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Jul 17;63(4):753–758. doi: 10.1007/s00280-008-0792-9

Figure 2.

Figure 2

(A) The Binding of BCNU to MT2 at pH 7.0 and pH 7.4. Results show that the addition of BCNU to a solution containing PAR and MT2 leads to increase in absorbance at 485 nm, due to the conjugation of PAR to the divalent cations Cd+2 and Zn+2 (depicted in the lower panel in the middle). The binding of BCNU to MT2 is faster at pH 7.4 than at pH 7.0, (B) BCNU also decomposes twice as fast at pH 7.4 than at pH 7.0.