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. Author manuscript; available in PMC: 2013 Apr 25.
Published in final edited form as: J Neurochem. 2010 Dec 1;117(2):187–196. doi: 10.1111/j.1471-4159.2010.07103.x

Fig. 5.

Fig. 5

Cold pre-conditioning and related effector cytokines increased hippocampal pyramidal layer interleukin-11 immunoreactivity. (a–d) We observed the most IL-11 immunoreactivity at the pyramidal cell layer in all groups. Here, we show faint and sparsely distributed IL-11 immunostaining under control conditions (a) that markedly increased 24 h after cold pre-conditioning CP (30°C for 90 min) (b), TNF-α exposure (TNF-α; 100 ng/mL) (c), and IL-1β exposure (IL-1β; 100 ng/mL) (d). (e) CP, TNF-α, and IL-1β (n = 9 per group) significantly (p < 0.001) increased the number of IL-11- immunopositive cells at the pyramidal cell layer. Scale bar, 50 µm.