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. Author manuscript; available in PMC: 2014 Mar 14.
Published in final edited form as: J Med Chem. 2013 Mar 1;56(5):2087–2096. doi: 10.1021/jm3017877

Figure 2.

Figure 2

(A) An overview of the X-ray crystal structure of TbrPDEB1, helices are colored yellow and labeled where visible, 310-helices are shown in fuchsia, and loops are shown in purple. The metal ions magnesium (lime) and zinc (gray) are shown. (B) A superposition of crystal structures of TbrPDEB1 (yellow), LmjPDEB1-IBMX (2R8Q in blue)12, TcrPDEC-WYQ16 (3V94 in green)4, and a crystal structure of hPDE4B-piclamilast (1XM4 in magenta).17 Close-ups of the region between Q874 on H15 and the M-loop are shown in: (C) TbrPDEB1; (D) LmjPDEB1; (E) TcrPDEC; and (F) hPDE4B.