Table 3. Clinicopathological correlations of candidate genes expression in CRC.
Variable | CXCL12 | CXCR4 | CXCR7 | IL8 | TGFB1 | TGFBR1 | TGFBR2 | CDH17 | CEA | FABP1 | MUC2 | PDCD4 |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Tumour diameter | 0.481 | 0.860 | 0.035* | 0.285 | 0.766 | 0.189 | 0.155 | 0.043* | 0.213 | 0.449 | 0.271 | 0.674 |
Tumour thickness | 0.094 | 0.242 | 0.036* | 0.616 | 0.348 | 0.317 | 0.234 | 0.035* | 0.282 | 0.049 | 0.654 | 0.052 |
Wall involvement | 0.019* | 0.005* | 0.002* | 0.055 | 0.201 | 0.000* | 0.006* | 0.002* | 0.002* | 0.949 | 0.400 | 0.886 |
Tumour location | 0.020* | 0.381 | 0.021* | 0.285 | 0.347 | 0.621 | 0.003* | 0.473 | 0.858 | 0.466 | 0.711 | 0.007* |
Tumour differentiation | 0.043* | 0.043* | 0.596 | 0.008* | 0.335* | 0.443 | 0.560 | 0.045* | 0.016* | 0.109 | 0.910 | 0.209 |
Mucin secretion | 0.342 | 0.272 | 0.679 | 0.115 | 0.585 | 0.225 | 0.870 | 0.407 | 0.782 | 0.398 | 0.013* | 0.217 |
Depth of invasion | 0.001* | 0.093 | 0.485 | 0.319 | 0.828 | 0.217 | 0.116 | 0.587 | 0.442 | 0.389 | 0.645 | 0.487 |
Lymph node status | 0.040* | 0.059 | 0.287 | 0.015* | 0.238 | 0.688 | 0.049* | 0.175 | 0.071 | 0.976 | 0.716 | 0.934 |
Distant metastasis | 0.163 | 0.044* | 0.138 | 0.062 | 0.861 | 0.161 | 0.235 | 0.434 | 0.547 | 0.373 | 0.938 | 0.443 |
Perineural invasion | 0.389 | 0.126 | 0.904 | 0.670 | 0.792 | 985 | 0.030* | 0.180 | 0.154 | 0.057 | 0.443 | 0.969 |
LV invasion | 0.033* | 0.132 | 0.020* | 0.0687 | 0.035 | 0.208 | 0.012* | 0.016* | 0.019* | 0.515 | 0.131 | 0.600 |
Tumour stage | 0.016* | 0.253 | 0.749 | 0.676 | 0.490 | 0.534 | 0.370 | 0.949 | 0.681 | 0.704 | 0.911 | 0.649 |
Recurrence | 0.169 | 0.058 | 0.124 | 0.036* | 0.476 | 0.126 | 0.213 | 0.891 | 0.801 | 0.170 | 0.685 | 0.023* |
*Statistically significant (P<0.05)