Table 2.

Associations of 11q23 rs498872T allele with glioma risk stratified by tumor IDH1/2 mutation status in UCSF Adult Glioma and Mayo Clinic Studies

Histology	IDH1/2-wild-type gliomas				Test for heterogeneity by study site	IDH1/2-mutated gliomas				Test for heterogeneity by study site
			case-control association					case-control association
	Number	RAF	OR (95% CI)	P value	P value	Number	RAF	OR (95% CI)	P value	P value
Controls	5299	0.31				5299	0.31
All gliomas	723	0.29	0.91 (0.81–1.03)	0.14	0.32	379	0.41	1.50 (1.29–1.74)	1.3E-07	0.11
Glioblastomas	607	0.29	0.91 (0.80–1.04)	0.17	0.24	56	0.43	1.65 (1.14–2.40)	0.008	0.28
Gr 2 Gliomas	36	0.29	0.93 (0.56–1.53)	0.77	0.69	188	0.39	1.38 (1.12–1.71)	0.002	0.35
Gr 3 Gliomas	80	0.29	0.90 (0.64–1.27)	0.54	0.74	135	0.43	1.59 (1.25–2.03)	1.8E-04	0.27
Oliodendrogliomas Gr 2/3	23	0.24	0.72 (0.37–1.40)	0.33	0.95	111	0.41	1.52 (1.16–1.99)	0.002	0.31
Oliogoastrocytomas Gr 2/3	9	0.28	0.86 (0.31–2.39)	0.78	NA*	78	0.38	1.29 (0.93–1.79)	0.134	0.17
Astrocytomas Gr 2/3	84	0.30	0.97 (0.70–1.34)	0.84	0.93	134	0.41	1.53 (1.20–1.96)	5.5E-04	0.80

*All IDH-wild-type oligoastrocytomas are from UCSF.

ORs from additive model for 0, 1, or 2T alleles in rs498872 are adjusted for study site. P values ≤.05 are in bold. RAF = risk allele frequency.