Table 3.
Case-control ORs of IDH1/2–mutated gliomas with rs498872 T allele and rs55705857 G allele in UCSF Adult Glioma and Mayo Clinic Studies
| Variable | Number | rs498872 (T allele) |
rs55705857 (G allele) |
||||
|---|---|---|---|---|---|---|---|
| RAF | OR (95% CI) | P value | RAF | OR (95% CI) | P value | ||
| Controls | 1300 | 0.32 | 0.05 | ||||
| IDH mutated tumors | |||||||
| All gliomas | 359 | 0.42 | 1.52 (1.27–1.83) | 5.1E-06 | 0.19 | 5.21 (3.90–6.96) | 6.8E-29 |
| Glioblastomas | 48 | 0.46 | 1.84 (1.19–2.85) | 6.2E-03 | 0.22 | 7.55 (4.12–13.9) | 6.5E-11 |
| Gr 2 Gliomas | 180 | 0.39 | 1.42 (1.12–1.80) | 4.3E-03 | 0.21 | 5.56 (3.93–7.88) | 4.5E-22 |
| Gr 3 Gliomas | 131 | 0.44 | 1.60 (1.23–2.07) | 4.4E-04 | 0.16 | 4.25 (2.83–6.38) | 2.8E-12 |
| Oliodendrogliomas Gr 2/3 | 107 | 0.42 | 1.60 (1.18–2.16) | 2.3E-03 | 0.20 | 5.89 (3.83–9.07) | 7.6E-16 |
| Oliogoastrocytomas Gr 2/3 | 74 | 0.39 | 1.33 (0.95–1.88) | 0.10 | 0.16 | 3.73 (2.30–6.04) | 9.0E-08 |
| Astrocytomas Gr 2/3 | 130 | 0.42 | 1.54 (1.18–2.02) | 1.7E-03 | 0.19 | 5.37 (3.59–8.04) | 3.4E-16 |
Note: Fewer subjects had data available for rs55705857 than for rs498872 because only a recently completed custom genotyping panel22 contained rs55705857.
ORs for each glioma subtype are from an additive model that includes both 0, 1, or 2 T alleles in rs498872 and 0, 1, or 2 G alleles in rs55705857 and is adjusted for study site. P values ≤ .05 are in bold.
RAF = risk allele frequency.