Table 2.

Pathological and molecular parameters

Parameter	Available cases		Spontaneous VDE			P value
			Mean ± SD	Median	Range
Histological subtype	407					.891
Astrocytoma		76	5.7 ± 6.6	3.7	0.2–35.8
Oligodendroglioma		246	5.8 ± 6.5	4.0	0.2–42.4
Mixed glioma		85	5.7 ± 5.6	3.9	0.2–24.3
1p19q codeletion	205					.008
Yes		67	4.6 ± 5.7	2.9	0.3–34.1
No		138	6.2 ± 6.1	4.6	0.2–42.4
1p deletion (complete)	206					.009
Yes		64	4.6 ± 5.7	2.8	0.3–34.1
No		142	6.1 ± 6.1	4.6	0.2–42.4
1p deletion (partial)	206					.446
Yes		17	6.3 ± 5.5	5.6	0.9–21.1
No		189	5.6 ± 6.1	3.9	0.2–42.4
19q deletion	205					.173
Yes		94	5.6 ± 6.9	3.9	0.3–42.4
No		111	5.8 ± 5.3	4.4	0.2–24.3
Proliferation rates	195					.620
<5%		124	5.7 ± 5.2	3.9	0.2–31.0
≥5%		71	5.2 ± 6.3	3.3	0.3–34.4
EGFR amplification	193					.669
Yes		183	6.7 ± 6.3	4.8	1.0–19.9
No		10	5.9 ± 6.5	4.2	0.3–42.4
10q deletion	181					.649
Yes		153	5.8 ± 5.4	4.9	0.3–22.6
No		28	5.6 ± 6.2	3.8	0.2–42.4
p53 overexpression	144					.004
Yes		64	7.7 ± 7.8	5.1	0.3–34.1
No		80	4.5 ± 4.5	3.4	0.4–31.0
Internexin alpha expression	39					.955
Yes		21	6.2 ± 7.8	3.4	0.4–31.0
No		18	6.3 ± 9.2	3.4	0.5–33.8
IDH1 expression	32					.245
Yes		25	7.3 ± 8.8	3.8	0.4–24.7
No		7	2.9 ± 1.3	2.9	1.0–5.0